Mucosal Healing: A New Paradigm in IBD Treatment

Traditionally, the primary goal of inflammatory bowel disease (IBD) treatment was for patients to achieve “clinical remission”, defined by the absence of signs and symptoms of active disease.[i] More recently, focus has shifted to the induction of “mucosal healing”, a state defined not only by the absence of clinical symptoms, but also the absence of […]

Immuno-resolution: The Next Frontier for Treating Inflammatory Diseases

Uncontrolled inflammation is an important component of many chronic diseases, including arthritis, asthma, psoriasis, arteriosclerosis, and inflammatory bowel disease (IBD). Treatment of these diseases often utilizes anti-inflammatory agents that block steps in the inflammatory response and suppress the immune system. Unfortunately, such agents are only partially effective and can lead to undesirable side effects such […]

Bioactive Lipids and Gastrointestinal Inflammation

Inflammation is the protective biological response to infection, irritation, and injury. The inflammatory response is vital to survival, but can cause inadvertent damage if not carefully controlled. This is particularly true in the gastrointestinal (GI) tract, which is home to trillions of microbes and constantly exposed to inflammatory stimuli. As a result, the inner lining […]